Pharmacological Effects of 2-Aminotetralins, Octahydrobenzo[F]Quinolines and Clonidine on the Isolated Guinea Pig Ileum
Document Type
Article
Publication Date
5-22-1981
Description
The ability of derivatives of 2-aminotetralins (2AT), cis- or trans-isomers of octahydrobenzo[f]quinolines (BfQ) and clonidine to modulate acetylcholine release was studied using field-stimulated guinea pig ilea (GPI). Antihistaminic and antiacetylcholine activities were also determined using isolated superfused segments of GPI. Hydroxylated 2AT, BfQ and clonidine inhibited field stimulation-induced contractions through α-adrenoceptor mechanisms which were antagonized by phentolamine. In contrast, the inhibition produced by nonhydroxylated 2AT was not attenuated by α-adrenoceptor antagonism. 2AT, trans-7,8-dihydro-BfQ and cis-8,9-dihydroxy-BfQ inhibited contractions induced by nicotine bitartrate using superfused GPI. Clonidine was inactive as an antinicotinic agent and there was no correlation between a compound's ability to inhibit contractions induced by field stimulation and its antinicotinic activity. Various 2AT derivatives demonstrated weak antimuscarinic and/or antihistaminic activities on superfused ileal segments. These data demonstrate that these agents posses a spectrum of pharmacological activity.
Citation Information
Maixner, William; Arnerić, Stephen P.; Abou Zeit-Har, Mohamed S.; Lecompte, Jocelyn; Verimer, Türkiz; Cannon, Joseph G.; Lee, Theresa; and Long, John P.. 1981. Pharmacological Effects of 2-Aminotetralins, Octahydrobenzo[F]Quinolines and Clonidine on the Isolated Guinea Pig Ileum. European Journal of Pharmacology. Vol.71(4). 475-482. https://doi.org/10.1016/0014-2999(81)90192-8 PMID: 6113972 ISSN: 0014-2999