Effects of Capsaicin on Release of Substance P-Like Immunoreactivity and Physiological Parameters in Isolated Perfused Guinea-Pig Heart

Document Type

Article

Publication Date

9-23-1987

Description

Release of substance P-like immunoreactivity (SP-LI) was measured from isolated perfused guinea-pig hearts. Capsaicin (1 μM) caused a substantial increase in the amount of SP-LI detected in perfusate compared to values during exposure to vehicle or drug-free buffer. Tachyphylaxis developed to the effect of capsaicin on release of SP-LI and to its effect on physiological parameters. These data show SP-LI can be released from cardiac sensory nerves and suggest SP could mediate a portion of the response of the isolated heart to capsaicin.

Share

COinS