Dopamine Receptor Plasticity Following MPTP-Induced Nigrostriatal Lesions in the Mouse
Document Type
Article
Publication Date
5-16-1990
Description
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) destroys dopamine-containing nigrostriatal neurons and increases the apparent Bmax of both D1 and D2 binding sites in the striatum. However, the changes of Bmax occur at different intervals after the lesion. Up-regulation of D2 sites becomes evident about 3 weeks after the lesion and lasts for about 3 months. In contrast, about 3 months are required for the up-regulation of D1 sites and increased binding is still evident after 5 months.
Citation Information
Weihmuller, Frederic B.; Bruno, John P.; Neff, Norton H.; and Hadjiconstantinou, Maria. 1990. Dopamine Receptor Plasticity Following MPTP-Induced Nigrostriatal Lesions in the Mouse. European Journal of Pharmacology. Vol.180(2-3). 369-372. https://doi.org/10.1016/0014-2999(90)90324-Y PMID: 2365010 ISSN: 0014-2999