Angiotensin II Receptor Subtypes in the Rat Brain
Document Type
Article
Publication Date
9-21-1990
Description
The non-peptide angiotensin II (AII) receptor subtype selective antagonist, DuP 753, was used to characterize AII receptor binding sites in the rat brain. DuP 753 competed for specific 125I-[Sar1, Ile8]AII (125I-SIAII) binding in many brain nuclei (IC50 = 20-30 nM), but was a weak competitor at remaining sites (IC50 > 10-4 M). DuP 753 sensitive binding sites (designated AIIα subtype) correspond with areas where binding is inhibited by sulfhydryl reducing agents, whereas DuP 753 insensitive sites (AIIβ) correspond with areas where binding is not inhibited by sulfhydryl reducing agents.
Citation Information
Rowe, Brian P.; Grove, Kevin L.; Saylor, David L.; and Speth, Robert C.. 1990. Angiotensin II Receptor Subtypes in the Rat Brain. European Journal of Pharmacology. Vol.186(2-3). 339-342. https://doi.org/10.1016/0014-2999(90)90457-H PMID: 2289535 ISSN: 0014-2999