Ontogenetic Quinpirole Treatment Induces Vertical Jumping Activity in Rats
Document Type
Article
Publication Date
8-3-1993
Description
Repeated ontogenetic treatment with quinpirole produces enhanced quinpirole-induced yawning and antinociceptive actions in adult rats. We now report the occurence of a bizarre behavior jumping inrats so treated. Rats were treated daily from birth with quinpirole HCl (3.0 mg/kg per day × 28 days i.p., salt form) or saline vehicle. After each daily injection, the rats were observed for at least 1 h. Starting on the 18th day after birth, quinpirole treatment was associated with the appearance of jumping behavior. On the 20th day after birth a dose-effect relationship was found for quinpirole HCl (0.10-3.0 mg/kg), with maximal jumping activity occurring between 30 and 150 min after the 3.0 mg/kg dose. On the 26th day after birth, both spiperone HCl (0.30 mg/kg i.p.) and SCH 23390 HCl (0.30 mg/kg i.p.) attenuated the quinpirole effect. At 34 days the jumping response was virtually absent. The age-related jumping behavior appears to be another manifestation of the abnormal responses meduated by supersensitized dopamine receptors in quinpirole-primed rats. Based on the ability of dopamine D1 and D2 receptor antagonists to attenuate this effect, quinpirole-induced jumping behavior may be a reflection of cooperativity of dopamine D1 and D2 receptor types.
Citation Information
Kostrzewa, Richard M.; Guo, Jinping; and Kostrzewa, Florence P.. 1993. Ontogenetic Quinpirole Treatment Induces Vertical Jumping Activity in Rats. European Journal of Pharmacology. Vol.239(1-3). 183-187. https://doi.org/10.1016/0014-2999(93)90992-Q PMID: 7901028 ISSN: 0014-2999