Foreign-Body-Associated Experimental Osteomyelitis Induced With Bacteroides Fragilis and Staphylococcus Epidermidis in Rabbits
Document Type
Article
Publication Date
1-1-1991
Description
Bacteroides fragilis and Staphylococcus epidermidis, alone and in combination, were used to induce foreign-body-associated osteomyelitis in a rabbit model. In this model, a catheter, used as a foreign body, was implanted into the medullary cavity of the tibia. Only two of five animals infected with S. epidermidis alone developed culture-positive osteomyelitis, whereas all three animals infected with B. fragilis alone developed osteomyelitis. All six animals infected with both microorganisms developed culture-positive osteomyelitis. Roentgenographic and histologic evaluations confirmed the diagnosis of osteomyelitis. Transmission and scanning electron microscopy showed that when the two microorganisms are involved in a mixed infection, S. epidermidis predominates on the foreign body and B. fragilis predominates in the infected bone and marrow.
Citation Information
Lambe, D. W.; Ferguson, K. P.; Mayberry-Carson, K. J.; Tober-Meyer, B.; and Costerton, J. W.. 1991. Foreign-Body-Associated Experimental Osteomyelitis Induced With Bacteroides Fragilis and Staphylococcus Epidermidis in Rabbits. Clinical Orthopaedics and Related Research. (266). 285-294. https://doi.org/10.1097/00003086-199105000-00040 PMID: 2019061 ISSN: 0009-921X