Title
In Vitro Interactions of Amikacin and Beta-Lactam Antibiotics Against Amikacin-Resistant Gram-Negative Bacilli
Document Type
Article
Publication Date
1-1-1988
Description
We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combination by the checkerboard technique, while amikacin-cefoperazone was the most active combination by the time-killing curve technique against Pseudomonas aeruginosa. Discrepancies were found between the results of the two methods used.
Citation Information
Alvarez, Salvador; Jones, Mary; Holtsclaw-Berk, Shirley; and Berk, Steven L.. 1988. In Vitro Interactions of Amikacin and Beta-Lactam Antibiotics Against Amikacin-Resistant Gram-Negative Bacilli. Chemotherapy. Vol.34(2). 107-112. https://doi.org/10.1159/000238556 PMID: 3391050 ISSN: 0009-3157