Cell-Mediated Hyperacute Rejection. II. The Early Events

Document Type

Article

Publication Date

3-15-1981

Description

The "white graft" reaction, the most severe form of cell-mediated hyperacute rejection reactions, results in early graft death, demonstrable by failure of syngeneic retransplantation beginning about 24 hr after placement onto the sensitized recipients. This is preceded by ultrastructural necrotic changes of graft endothelial cells, beginning about 6 hr after graft placement. The likely rejection mechanisms and immune pathways are discussed.

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