Defective Bursa Regeneration After Irradiation of Young Thymectomized Chickens
Document Type
Article
Publication Date
1-1-1984
Description
The ability of the bursa of Fabricius to regenerate after γ-irradiation and bone marrow reconstitution was examined in chickens thymectomized (TX) immediately after hatching. Irradiation (2 × 500 R) 3 weeks after hatching was followed by impaired bursa regeneration, as judged both by bursa/body weight ratios and by bursa follicle development 3-6 weeks later in TX as compared to control birds. Germinal center formation in the spleen was deficient, and immune responses to sheep erythrocytes (SRBC) and B. abortus (BA) were moderately reduced in the TX as compared to control birds irradiated at 3 weeks but not in TX birds irradiated at 5 weeks of age.
Citation Information
Bhogal, Balbir S.; Chi, David S.; Galton, Jane E.; Bell, Melvin K.; and Thorbecke, G. Jeanette. 1984. Defective Bursa Regeneration After Irradiation of Young Thymectomized Chickens. Cellular Immunology. Vol.87(1). 159-166. https://doi.org/10.1016/0008-8749(84)90140-0 PMID: 6378392 ISSN: 0008-8749