Prolactin-Releasing Peptide-Immunoreactivity in A1 and A2 Noradrenergic Neurons of the Rat Medulla
Document Type
Article
Publication Date
3-20-1999
Description
Distribution of prolactin-releasing peptide-like immunoreactivity (PrRP- LI) was investigated in the rat medulla with the use of a rabbit polyclonal antiserum against the human PrRP-31 peptide. PrRP-positive neurons were noted mainly in two areas of the caudal medulla: ventrolateral reticular formation and commissural nucleus of the nucleus of the solitary tract (NTS), corresponding to the A1 and A2 areas. PrRP-LI neurons were absent in the medulla rostral to the area postrema. Double-labeling the sections with PrRP antisera and tyrosine hydroxylase (TH) monoclonal antibodies revealed extensive colocalization of PrRP- and TH-like immunoreactivity (TH-LI) in neurons of the A1 and A2 areas. Our results show that PrRP-LI is expressed in a population of A1 and A2 noradrenergic neurons of the rat caudal medulla.
Citation Information
Chen, C. T.; Dun, S. L.; Dun, N. J.; and Chang, J. K.. 1999. Prolactin-Releasing Peptide-Immunoreactivity in A1 and A2 Noradrenergic Neurons of the Rat Medulla. Brain Research. Vol.822(1-2). 276-279. https://doi.org/10.1016/S0006-8993(99)01153-1 PMID: 10082910 ISSN: 0006-8993