Effect of Long-Term Therapy With an Oral Contraceptive on Some Aspects of Hepatic Lipid Metabolism in Vitro
Document Type
Article
Publication Date
9-1-1975
Description
Livers were obtained from untreated controls as well as from female rats which were treated with Enovid® (7.5 mg/kg of food) for either 4 days or 1 year. The livers were placed in an isolated perfusion system and the rate of release of cholesterol and triglyceride was measured. Long-term treatment with Enovid® resulted in a 38-72 per cent reduction below control level in the rate of release of hepatic triglyceride and cholesterol, respectively, while short-term treatment was without a significant effect. No significant effect of either short- or long-term treatment was observed on hepatic weight or on concentrations of either cholesterol or triglyceride in the liver at the end of the perfusion. Concentrations of triglyceride and cholesterol in the serum of the liver donors were also measured. The only significant change observed was a 30 per cent reduction in cholesterol concentration of the group treated with Enovid® for 4 days. Thus, treatment with Enovid® for 1 year was accompanied by a reduced rate of release of cholesterol and triglyceride by the liver, while serum triglyceride and cholesterol concentrations were unchanged. Studies of other aspects of the metabolism of these two substances will be necessary to explain the results.
Citation Information
Weinstein, Ira; Belitsky, Richard; Seedman, Susan; Fregly, Melvin J.; and Thrasher, Terry N.. 1975. Effect of Long-Term Therapy With an Oral Contraceptive on Some Aspects of Hepatic Lipid Metabolism in Vitro. Biochemical Pharmacology. Vol.24(17). 1583-1588. https://doi.org/10.1016/0006-2952(75)90083-0 PMID: 1191317 ISSN: 0006-2952