Persistence of Long-Lasting Serotonin Depletion by P-Chloroamphetamine in Rat Brain After 6-Hydroxydopamine Lesioning of Dopamine Neurons
Document Type
Article
Publication Date
10-12-1995
Description
In rats that had been treated neonatally with 6-hydroxydopamine (6OHDA) to deplete striatal dopamine more than 95%, a single injection of p-chloroamphetamine (pCA) (5 or 10 mg/kg, i.p.) resulted in depletion of striatal and hippocampal serotonin at 1 week to a similar extent as in control rats. These findings suggest that striatal dopamine is not essential to the long-lasting depletion of brain serotonin by pCA in rats.
Citation Information
Perry, Kenneth W.; Kostrzewa, Richard M.; and W. Fuller, Ray. 1995. Persistence of Long-Lasting Serotonin Depletion by P-Chloroamphetamine in Rat Brain After 6-Hydroxydopamine Lesioning of Dopamine Neurons. Biochemical Pharmacology. Vol.50(8). 1305-1307. https://doi.org/10.1016/0006-2952(95)00248-X PMID: 7488249 ISSN: 0006-2952