In Vitro Influence of Fatty Acids on the Mitochondrial Urea Cycle Enzymes and Substrate Inhibition Following Polychlorinated Biphenyl Treatment

Document Type

Article

Publication Date

1-1-1978

Description

Fatty acids inhibit mitochondrial Carbamyl Phosphate Synthesase (CPS I) and Ornithine transcarbamylase (OTC) when preincubated with liver homogenates. Aroclor 1254 given intraperitoneally at 100 mg kg 24 hr causes an apparent inhibition of CPS I and OTC by their substrates and an increase in liver size. The correlation of inhibition of OTC and enlargement of the liver indicates that Aroclor 1254 treatment inhibits the mitochondrial urea cycle enzymes both directly, and indirectly by increasing the content of fatty acids and triglyceride accumulation.

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