Effects of Platelet Activating Factor on Mouse Oocyte Fertilization in Vitro

Creator(s)

Brijinder S. Minhas, Quillen-Dishner College of Medicine
Raj Kumar, University of Texas Health Science Center at San Antonio
Deborah D. Ricker, Quillen-Dishner College of Medicine
William E. Roudebush, Quillen-Dishner College of Medicine
Melvin G. Dodson, Quillen-Dishner College of Medicine
Stephen J. Fortunato, Quillen-Dishner College of Medicine

Document Type

Article

Publication Date

1-1-1989

Description

Platelet activating factor is rapidly gaining acceptance as a potent mediator in many reproductive processes. This study presents data that indicate a direct role of platelet activating factor in fertilization. Platelet activating factor was shown to significantly increase (p < 0.001) the fertilization rate of mouse oocytes in vitro. Furthermore, CV3988, an inhibitor of platelet activating factor, was noted to significantly decrease in vitro fertilization rates at 10-5 and 10-4 mol/L concentrations. kw]Platelet activating factor, in vitro fertilization fa]Presented in part at the Thirty-sixth Annual Meeting of the Society for Gynecologic Investigation, San Diego, California, March 15-18, 1989.

Citation Information

Minhas, Brijinder S.; Kumar, Raj; Ricker, Deborah D.; Roudebush, William E.; Dodson, Melvin G.; and Fortunato, Stephen J.. 1989. Effects of Platelet Activating Factor on Mouse Oocyte Fertilization in Vitro. American Journal of Obstetrics and Gynecology. Vol.161(6 PART 1). 1714-1717. https://doi.org/10.1016/0002-9378(89)90956-3 PMID: 2603931 ISSN: 0002-9378