Clindamycin Therapy for Chlamydia Trachomatis in Women
Document Type
Article
Publication Date
1-1-1990
Description
The population for this study consisted of 4013 sexually active women seen for family planning. Culture for Chlamydia trachomatis yielded an isolation rate of 6.1%. Women aged 16 to 25 accounted for 81.7% of the C. trachomatis infections, while those younger than 16 or older than 35 accounted for only 2.4% of the infections. Of the 246 patients whose cultures were positive for C. trachomatis, 159 (65%) were asymptomatic. The incidence of C. trachomatis was 11.2% among those with symptoms but only 6.4% among the asymptomatic group. Among 63 patients with Neisseria gonorrhoeae (who were excluded from the study), 26 (41.3%) also were infected by C. trachomatis. There were no microbiologic drug failures with erythromycin or clindamycin. Of 56 patients who enrolled in the clindamycin arm of the protocol, 48 (85.7%) completed therapy and experienced microbiologic and clinical cures. In contrast, erythromycin therapy was completed by only 25 of 57 women (43.9%) enrolled. The number of side effect failures for erythromycin was 22 of 57 (38.6%). This was more than five times the number of side effect failures for clindamycin (4 of 56, or 7.1%).
Citation Information
Campbell, William F.; and Dodson, Melvin G.. 1990. Clindamycin Therapy for Chlamydia Trachomatis in Women. American Journal of Obstetrics and Gynecology. Vol.162(2). 343-347. https://doi.org/10.1016/0002-9378(90)90382-H PMID: 2178426 ISSN: 0002-9378