Title
Outpatient Conversion of Treatment to Potassium-Sparing Diuretics
Document Type
Article
Publication Date
1-1-1986
Description
Thiazide diuretics frequently cause a decrease in serum potassium levels. In this study, 34 percent of patients taking hydrochlorothiazide had serum potassium levels below 3.5 meq/liter. The response of the serum potassium level was studied after treatment in 56 patients was switched from 50 mg of hydrochlorothiazide daily to either two capsules of hydrochlorothiazide/triampterene (Dyazide), or one tablet of hydrochlorothiazide/amiloride (Moduretic) daily, over nine to 15 months. The 24 patients whose treatment was changed to Dyazide had a rise in serum potassium levels from a mean of 3.56 meq/liter to 4.17 meq/liter in two to three weeks. The 32 patients whose treatment was changed to Moduretic had a rise in serum potassium levels from a mean of 3.76 meq/liter to 4.14 meq/liter in two to three weeks. The resultant rise in potassium levels was stable throughout the follow-up period in both groups. Patient acceptance of this change was excellent.
Citation Information
Ridgeway, Nathan A.; Ginn, David R.; and Alley, Kay. 1986. Outpatient Conversion of Treatment to Potassium-Sparing Diuretics. The American Journal of Medicine. Vol.80(5). 785-788. https://doi.org/10.1016/0002-9343(86)90616-9 PMID: 3706365 ISSN: 0002-9343