T Cell Signaling of Macrophage Function in Inflammatory Disease.
Document Type
Review
Publication Date
1-1-1997
Description
Macrophages play diverse roles in episodic T cell-mediated inflammatory diseases such as multiple sclerosis and rheumatoid arthritis, function as accessory cells for T cell activation, as pro-inflammatory cells, as effector cells which mediate tissue damage, and as anti-inflammatory cells which promote wound healing. In addition to the many roles of T cell-derived cytokines in differentially modulating these diverse macrophage activities, research over the last few years has demonstrated that contact-dependent signaling which occurs during T cell-macrophage adhesion is a critical triggering event in the activation of macrophage function. Substantial research emphasis has been placed on CD40 as a mediator of contact dependent signaling. However, other membrane-anchored receptor:ligand pairs may also contribute to the stimulation of macrophage function. This is a brief review of the rapidly expanding, but still incomplete, knowledge of how T cells, through both contact-dependent and cytokine signals, regulate macrophage function during inflammatory disease.
Citation Information
Stout, R. D.; and Suttles, J.. 1997. T Cell Signaling of Macrophage Function in Inflammatory Disease.. Frontiers in bioscience : a journal and virtual library. Vol.2 https://doi.org/10.2741/A183 PMID: 9206987