Identification of a New v(κ) Gene Family That Is Highly Expressed in Hybridomas From an Autoimmune Mouse Strain
Document Type
Article
Publication Date
1-1-1990
Description
We have identified a new murine V(κ) family that contains five to seven members, one member of which encodes the L chain V region of an anti-dsDNA antibody produced by a BALB/c hybridoma, C8.5. The cloned C8.5 V(κ) gene exhibits highest homology with a human V(κ) gene that was cloned from a nonproductive rearrangement but has never been seen in an expressed repertoire. Because this family was first identified in an autoantibody, we studied its expression in an autoimmune mouse strain. This V(κ) family is expressed in 20% of hybridomas from NZB mice.
Citation Information
Shefner, R.; Mayer, R.; Kaushik, A.; D'Eustachio, P.; Bona, C.; and Diamond, B.. 1990. Identification of a New v(κ) Gene Family That Is Highly Expressed in Hybridomas From an Autoimmune Mouse Strain. Journal of Immunology. Vol.145(5). 1609-1614. https://www.jimmunol.org/content/145/5/1609 PMID: 1974568 ISSN: 0022-1767