Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Caused by Phenytoin
Document Type
Article
Publication Date
1-1-2017
Description
Drug rash with eosinophilia and systemic symptoms (DRESS) is a rare but potentially life-threatening condition with high mortality. Diagnosis is challenging due to variable clinical presentation and a protracted latency period following initiation of the offending drug. DRESS is a complex interplay that starts by introduction of the offending drug, reactivation of viruses and activation of the immune system. Herpes virus reactivation is considered a diagnostic marker and indicator of illness severity. Prompt recognition and the removal of offending agent remain the key to successful treatment. In cases of severe organ involvement, corticosteroids, immunoglobulins, antiviral and specialist consultation may be helpful. Here we present a case of a 36-year-old African-American male who presented with symptoms mimicking sepsis with an associated skin eruption that was diagnosed as DRESS.
Citation Information
Riaz, Muhammad; Ragsdale, Bruce D.; Rahman, Zia Ur; and Nigam, Gaurav. 2017. Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Caused by Phenytoin. BMJ Case Reports. Vol.2017 https://doi.org/10.1136/bcr-2017-220835 PMID: 28830901