Successful Stepdown Treatment of Pulmonary Histoplasmosis With Thrice-Weekly Liposomal Amphotericin B in a Hospital-Associated, Outpatient Infusion Centre: A Case Report
What is known and objective: Amphotericin is the preferred treatment for pulmonary histoplasmosis during pregnancy. The long half-life of amphotericin supports less than daily administration. Case summary: A 28-year-old pregnant woman diagnosed with recurrent pulmonary histoplasmosis was initiated on liposomal amphotericin 250 mg (4 mg/kg) intravenously daily. After 2 weeks, the patient was discharged and successfully received 250 mg thrice weekly at a hospital-associated outpatient infusion centre. After 6 weeks of outpatient treatment, a chest X-ray demonstrated no remaining disease and therapy was discontinued. What is new and conclusion: Administration of thrice-weekly liposomal amphotericin in a hospital-associated, outpatient infusion centre may be a promising option for stepdown treatment in patients unable to take itraconazole.
Lewis, P. O.; Khan, I.; and Patel, P.. 2018. Successful Stepdown Treatment of Pulmonary Histoplasmosis With Thrice-Weekly Liposomal Amphotericin B in a Hospital-Associated, Outpatient Infusion Centre: A Case Report. Journal of Clinical Pharmacy and Therapeutics. Vol.43(2). 269-272. https://doi.org/10.1111/jcpt.12609 PMID: 28806478 ISSN: 0269-4727