Degree Name

MS (Master of Science)



Date of Award


Committee Chair or Co-Chairs

Abbas Shilabin

Committee Members

Aleksey Vasiliev, Sean Fox


As antimicrobial resistance persistently disrupts the treatment of microbial infection, natural product chemistry has played a significant role in identifying novel drugs with novel modes of action critical to getting ahead of resistance. The primary goal of this project is to extract and identify potential novel antimicrobial natural products produced by Arthrobacter sp. Although underexplored, Arthrobacter sps. have been known to produce bioactive compounds with versatility; one such is a depsipeptide with quorum-sensing inhibitory activity.1 In this research, an Arthrobacter sp. TAJX1902, isolated from a soil sample, showed inhibitory activity against a filamentous indicator bacterium and a violacein-producing Janthinobacterium sp. Arthrobacter sp. TAJX1902 was cultured using rich medium broth and agar to extract and isolate metabolites. Isolated compounds were characterized via spectroscopic techniques, including 1D and 2D-NMR spectroscopy and GCMS analysis. Arthrobacter sp. TAJX1902 produces Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(phenylmethyl), and five other bioactive cyclic dipeptides (CDPs).

Document Type

Thesis - embargo


Copyright by the authors.

Available for download on Sunday, September 15, 2024