Deficiency of Ataxia Telangiectasia-Mutated Kinase (ATM) in Female Mice Preserves Heart Function in Response to Western-type Diet (WD) by Affecting Cardiac Remodeling

Faculty Mentor

Dr. Krishna Singh

Mentor Home Department

Biomedical Sciences

Short Abstract

Deficiency of ATM protein and consumption of a Western-type Diet (WD) independently associate with heart disease. Our lab has shown that ATM-deficient female mice have attenuated fat weight gain and preserved heart function in the presence of WD. Here we investigated the effect of ATM deficiency on cardiac remodeling parameters in female mice fed with WD. It is hypothesized that ATM deficiency alters myocardial remodeling in female mice, thereby preserving heart function.

Category

Science and Technology

Start Date

24-4-2023 9:30 AM

End Date

24-4-2023 9:45 AM

Location

D.P. Culp Center Room 219

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Apr 24th, 9:30 AM Apr 24th, 9:45 AM

Deficiency of Ataxia Telangiectasia-Mutated Kinase (ATM) in Female Mice Preserves Heart Function in Response to Western-type Diet (WD) by Affecting Cardiac Remodeling

D.P. Culp Center Room 219

Deficiency of ATM protein and consumption of a Western-type Diet (WD) independently associate with heart disease. Our lab has shown that ATM-deficient female mice have attenuated fat weight gain and preserved heart function in the presence of WD. Here we investigated the effect of ATM deficiency on cardiac remodeling parameters in female mice fed with WD. It is hypothesized that ATM deficiency alters myocardial remodeling in female mice, thereby preserving heart function.