The Impact of Ovariectomy on the Sympathetic Response Following Acute vs Prolonged Heart Failure
Faculty Mentor
Dr. Cerrone Foster
Mentor Home Department
Biological Sciences
Short Abstract
Cardiovascular Disease is the leading cause of death globally and studies show that men and women are impacted differently. Our hypothesis is estrogen loss exacerbates cardiac function with acute sympathetic stimulation and hypertrophy, but prolonged stimulation blunts the sympathetic response. Ovariectomized and Sham female mice were treated with isoproterenol to simulate chronic sympathetic stimulation and we measured heart function at 7, 14, 21, and 28 days. Preliminary results show estrogen loss significantly exacerbates the function and response of the heart.
Category
Science and Technology
Start Date
24-4-2023 11:30 AM
End Date
24-4-2023 11:45 AM
Location
D.P. Culp Center Room 271J
The Impact of Ovariectomy on the Sympathetic Response Following Acute vs Prolonged Heart Failure
D.P. Culp Center Room 271J
Cardiovascular Disease is the leading cause of death globally and studies show that men and women are impacted differently. Our hypothesis is estrogen loss exacerbates cardiac function with acute sympathetic stimulation and hypertrophy, but prolonged stimulation blunts the sympathetic response. Ovariectomized and Sham female mice were treated with isoproterenol to simulate chronic sympathetic stimulation and we measured heart function at 7, 14, 21, and 28 days. Preliminary results show estrogen loss significantly exacerbates the function and response of the heart.