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Biomedical Sciences Theses and Dissertations

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Theses/Dissertations from 2024 2024

The Role of Cardiac Mitochondria in Arrhythmias and Sudden Unexpected Death in Epilepsy in Models of Dravet Syndrome, Jessa L. Aldridge

Poly (ADP-Ribose) Polymerase-1 (PARP1) Expression in the Frontal Cortex and Hippocampus in Major Depressive Disorder (MDD) and Suicide, Ramona Faith Fulkerson

Regulation of CD4 T Cell Functions by ncRNA-mediated Signaling Pathways during Chronic Viral Infections, Lam Nguyen

Optimization of Vagus Nerve Stimulation (VNS) and the Use of Cervical VNS as a Treatment for Heart Failure with Reduced Ejection Fraction, Misty Owens

Validation of a Novel Heritable Rodent Model of Drug Abuse Vulnerability in Psychosis and Investigation of Therapeutic Targets, Loren D. Peeters

Exogenous Ubiquitin: Role in Myocardial Ischemia/Reperfusion Injury, and Macrophage Phenotype and Function, Paige Shook

Overcoming the Barrier to the Clinical Application of Naloxone: Application of Drug Delivery Technologies, Akeemat O. Tijani

Theses/Dissertations from 2023 2023

Intestinal Microbiome, Fecal Fermentation Profile, and Health Indices in HIV Infected Men versus Non-Infected Controls, Mary Andreae and Mary C. Andreae Mrs

Microsporidian Spores and the Integrin Binding Loop of the MADAM Protein Are Important for Integrin Signaling and Attachment to Host Cells, Cindy L. Barrett

Elucidation of the Role of Avocado WRI1 and WRI2 and Their Ability to Affect Oil Content and Composition When Co-expressed With PDAT1 and DGAT1, Jyoti Ranjan Behera

Flavonol Glucosylation: A Structural Investigation of the Flavonol Specific 3-O Glucosyltransferase Cp3GT, Aaron S. Birchfield

Effect of Macrophage Expressed α7 Nicotinic Acetylcholine Receptor (α7nAChR) on Migration of Macrophages During Inflammation, Kasey Keever

MET Alterations in Glioblastoma: Characterization of Patient-Derived Xenografts and Therapeutic Strategies, Anna Musket

Investigating the Role of Maternal Adiposity on Human Breast Milk and Preterm Infant Stool Short Chain Fatty Acid and Microbiome Profiles, Kristy L. Thomas

Theses/Dissertations from 2022 2022

Importance of the Microhabitat and Microclimate Conditions in the Northern Gray-cheeked Salamander (Plethodon montanus) Across an Elevation Gradient, Trevor Chapman

A Functional Study of Topological DNA Problem in Human T cells During Chronic Viral Infection, Xindi Dang

Knockdown of C. elegans NAD Kinases NADK-1 or NADK-2 Induces an Antioxidant Response Without Affecting Lifespan, Henry Gong

Investigating the PI3K/AKT/ATM Pathway, Telomeric DNA Damage, T Cell Death, and CRISPR/Cas9-mediated Gene Editing During Acute and Chronic HIV Infection, Sushant Khanal

Validation of the 40 Hz Auditory Steady State Response as a Pharmacodynamic Biomarker of Evoked Neural Synchrony, Muhammad Ummear Raza

The Mechanisms of Mitochondrial Dysfunction in T Cell Aging during Chronic Viral Infection, Madison B. Schank

Theses/Dissertations from 2021 2021

GABAergic-Related Pathology in the Anterior Cingulate Cortex of Postmortem Human Brain Tissue in Autism Spectrum Disorder, Gethien Andrew

Endothelial Heat Shock Protein A12B and Yes-associated Protein Cooperatively Promote Angiogenesis Following Myocardial Infarction, Min Fan

Trained Immunity Enhances the Immune Response and Maintains Microbiome Diversity in Aging and Sepsis, P. Spencer Gill

Genital Chlamydia Infection is Influenced by the Female Sex Hormones Estrogen and Progesterone in Vivo, Amy Gail Gravitte

Role of Ataxia Telangiectasia Mutated Kinase in Western-type Diet-induced Cardiac Outcomes under Basal and Ischemic Conditions, Mary Wingard

Theses/Dissertations from 2020 2020

Development, Expansion and Role of Myeloid-Derived Suppressor Cells in Post-Sepsis Immune Suppression, Tuqa Alkhateeb

Axonal Regrowth of Olfactory Sensory Neurons After Chemical Ablation and Removal of Axonal Debris by Microglia, Rudy Chapman

Prevention of Chronic Inflammation by Targeting Macrophage Integrin aDb2, Cady Forgey

Behavioral and Neurobiological Evidence of Epigenetic Transmission in the Neonatal Quinpirole Rodent Model of Schizophrenia, Wesley Gill

Understanding the Implications of Anandamide, an Endocannabinoid in an Early Land Plant, Physcomitrella patens, Md Imdadul Haq

Immune Activation Induces Telomeric DNA Damage, Reduces Memory Precursors, and Promotes Short-lived Effector T Cell Differentiation in Chronic HCV Infection, Lam Nguyen

A Novel Mode of Action of C-reactive Protein in Protecting Against Streptococcus pneumoniae Infection and Synergy with Antibiotics, Donald Ngwa

Chronic Effects of Methylphenidate on Neuronal Viability and Plasticity, Hannah Oakes

Protection Against Atherosclerosis by A Non-native Pentameric CRP that Shares its Ligand Recognition Functions with an Evolutionarily Distant CRP, Asmita Pathak

Roles of Endothelial Cell Heat Shock Protein A12B and β-glucan, a reagent for trained Immunity in the Regulation of Inflammation in Sepsis, Fei Tu

Theses/Dissertations from 2019 2019

Exploration of Ataxia Telangiectasia and Rad3-Related’s (ATR’s) Role in Cell Death Regulation: Implications in Development, Cancer, and Stroke, Brian Cartwright

The Distinct Expressions of Integrins αDβ2 and αMβ2 Differently Regulate Macrophage Migration in 3D Matrix in vitro and in Tissue during Inflammation, Kui Cui

Role of ATM in T Cell Dysfunction During Chronic Viral Infections, Juan Zhao

Theses/Dissertations from 2018 2018

The Combined Neuropharmacology and Toxicology of Major 'Bath Salts' Constituents MDPV, Mephedrone, and Methylone, Serena Allen

The Effect of Alcohol Consumption on Adipokine Secretion, Ashley DeGroat

Quantitative Studies of Amyloidogenic Protein Residue Interaction Networks and Abnormal Ammonia Metabolism in Neurotoxicity and Disease, Jeddidiah Griffin

Metabolic Plasticity in the Cellular Stress Response, Ying Li

HIV Integrase Inhibitor Pharmacogenetics and Clinical Outcomes: An Exploratory Association Study, Derek E. Murrell

Effects of Gender, Age, and Nutrition on Circadian Locomotor Activity Rhythms in the Flesh Fly Sarcophaga crassipalpis, Fritz Prohaska

Characterization of Acyltransferases and WRINKLED Orthologs Involved in TAG Biosynthesis in Avocado, Md Mahbubur Rahman

Virulence Regulation in Pseudomonas aeruginosa via the Alginate Regulators, AlgU and AlgR, the posttranscriptional regulator, RsmA, and the Two-component System, AlgZ/R, Sean Stacey

SIP-428, a SIR2 Deacetylase Enzyme and Its Role in Biotic Stress Signaling Pathway, Bal Krishna Chand Thakuri

Role of Ataxia-Telangiectasia Mutated Kinase in Cardiac Autophagy and Glucose Metabolism Under Ischemic Conditions, Patsy Thrasher

Investigating the Interaction of Monoamines and Diel Rhythmicity on Anti-Predator Behavior in an Orb-Weaving Spider, Larinioides cornutus (Araneae: Araneae), Rebecca Wilson

Theses/Dissertations from 2017 2017

Role of Cannabinoid Receptor Type 2 (CB2) in Late Stage Atherosclerosis, Makenzie Fulmer

A-type Lamins in Cell Cycle Regulation, Jaime L. Parman-Ryans

Exogenous Ubiquitin: Role in Myocardial Inflammation and Remodeling Post- Ischemia/Reperfusion Injury, Stephanie Scofield

Role of TLRs, Hippo-YAP1 Signaling, and microRNAs in Cardiac Repair and Regeneration of Damaged myocardium During Ischemic Injury, Xiaohui Wang

Theses/Dissertations from 2016 2016

An Investigation into Formulation and Therapeutic Effectiveness of Nanoparticle Drug Delivery for Select Pharmaceutical Agents, Dustin Cooper

Strategies of Balancing: Regulation of Posture as a Complex Phenomenon, Allison Leich Hilbun

Investigation of Novel Functions for DNA Damage Response and Repair Proteins in Escherichia coli and Humans, Benjamin A. Hilton

Exploring the Relationship Between Behaviour and Neurochemistry in the Polyphenic Spider, Anelosimus studiosus (Araneae: Theridiidae), Jennifer B. Price

In Vitro and In Vivo Characterization of Chlamydia and HSV Co-infection, Jessica A. Slade

A novel role of human DNA damage checkpoint protein ATR in suppressing Ca2+ overload-induced PARP1-mediated necrosis, Hui Wang-Heaton

Pharmacokinetics, Tissue Distribution, Synergistic Activity, and Antitumor Activity of Two Isomeric Flavones, Crystal L. Whitted

Regulation of Acute and Chronic Immune Responses by β-Arrestin2, Hui Yan

Endothelial HSPA12B is a Novel Protein for the Preservation of Cardiovascular Function in Polymicrobial Sepsis via Exosome MiR-126, Xia Zhang

Theses/Dissertations from 2015 2015

Role of Ataxia Telangiectasia Mutated Kinase in the Healing Process of the Heart Following Myocardial Infarction, Laura L. Daniel

Theses/Dissertations from 2014 2014

Cellular-based Brain Pathology in the Anterior Cingulate Cortex of Males with Autism Spectrum Disorder, Jessica D. Crawford

Extracellular Ubiquitin: Role in Cardiac Myocyte Apoptosis and Myocardial Remodeling, Christopher Ray Daniels

Novel Therapeutic Approaches for Ischemic Heart and Brain Injury: Modulation of Toll-Like Receptor-Mediated Signaling Pathways and PI3K/Akt Signaling, Chen Lu

Regulation of C-reactive Protein Gene Expression and Function, Avinash N. Thirumalai

A Comprehensive Study of the Effects of Neurotoxins on Noradrenergic Phenotypes, Neuronal Responses and Potential Intervention by Antidepressants in Noradrenergic Cells, Yan Wang

HIF-1α in the Heart: Provision of Ischemic Cardioprotection and Remodeling of Nucleotide Metabolism, Joe Wu

Theses/Dissertations from 2013 2013

An Examination of the Inhibitory Effects of Antibiotic Combinations on Ribosome Biosynthesis in Staphylococcus aureus, Justin Beach

Genetic Imbalances in Endometriosis Detected by Oligonucleotide-Array Based Comparative Genomic Hybridization, Natalie Burke

Arrested and Aberrant: Effects of Amoxicillin in a Murine Model of Chlamydial Infection, Regenia Beth Phillips Campbell

Identification and Characterization of Genetic Factors Involved in Candida-Bacterial Interactions, Sean J. Fox

Mechanisms of the Anti-Pneumococcal Function of C-Reactive Protein, Toh B. Gang

Microsporidia Spore Adherence and Host Cell Infection In Vitro, Cory A. Leonard

New Insights into the Roles of Human DNA Damage Checkpoint Protein ATR in the Regulation of Nucleotide Excision Repair and DNA Damage-Induced Cell Death, Zhengke Li

Novel Ester Substrates for the Detection and Treatment of Prostate Cancer, Christopher Allen McGoldrick

Novel Roles of Replication Protein A Phosphorylation in Cellular Response to DNA Damage, Moises A. Serrano

Bioengineering the Expression of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, and C-Reactive Protein in Yeast, Eliot T. Smith

Theses/Dissertations from 2012 2012

Prelamin A Influences a Program of Gene Expression In Regulation of Cell Cycle Control, Christina N. Bridges

Detection and Purification of a Novel Natural Inhibitory Compound from an Isolated Strain of Rhodococcus Using an Agar Extraction Method, Megan Carr

An Investigation of Bacterial Ribonucleases as an Antibiotic Target, Ashley Denise Frazier

Stabilization of the Cardiac Nervous System During Cardiac Stress Induces Cardioprotection, David D. Gibbons

The Effects of Nicotine Administration on Behavior and Markers of Brain Plasticity in a Rodent Model of Psychosis, Marla K. Perna

Effects of Burn Injury on Biological Ethanol and Ethyl Glucuronide Concentrations, Trista Haupt Wright

Theses/Dissertations from 2011 2011

Role of Type 2 Cannabinoid Receptor (CB2) in Atherosclerosis., Courtney Denise Netherland

Biopharmaceutic and Pharmacokinetic Studies of Sucrose Acetate Isobutyrate as an Excipient for Oral Drug Delivery., Martin Ray Tant

Theses/Dissertations from 2010 2010

The Effect of Sternocleidomastoid Muscle Activation Pattern and Feedback Condition on the Vestibular Evoked Myogenic Potential., Mary Jo Davenport

Mosaic Analysis with Double Markers (MADM) as a Method to Map Cell Fates in Adult Mouse Taste Buds., Preston D. Moore

The Multifaceted Contribution of Natural Killer Cells During Herpes Simplex Type-1 Viral Infection., Stacie N. Woolard

Theses/Dissertations from 2009 2009

Determining Putative Secondary Product Glucosyltransferase Expression During Citrus paradisi Growth and Development., Jala Daniel

Dopamine D2 Receptor Priming Enhances Dopaminergic Response to Amphetamine in the Nucleus Accumbens: Role of the D1 and D2 Receptors., Kimberly Norris Huggins

Localization of Calbindin-D_28k in Extra-Embryonic Membranes of Two Oviparous Scincid Lizards., Shuo Li

Nectin-1 is Degraded in Chlamydia trachomatis-Infected Genital Epithelial Cells and is Required for Herpes Simplex Virus Co-Infection-Induced C. trachomatis Persistence., Jingru Sun

Theses/Dissertations from 2008 2008

Elucidating the Role of the α7 Nicotinic Receptor in the Etiology of Schizophrenia., Michelle Johnson Chandley

Identification of Chlamydial Iron-Responsive Proteins during Intracellular Growth., Brian D. Dill

Antigen Trafficking within Chlamydia trachomatis-Infected Polarized Human Endometrial Epithelial Cells., David Kelley Giles

Urinary Excretion of (1-3)-Beta-D-Glucans., Debra K. Head

Expression, Purification, and Characterization of the Mast Cell Proteases Chymase and Cathepsin G., Brent E. Lockhart

Characterization of Murine Cardiac Cholinergic Innervation and Its Remodeling in Type 1 Diabetes., Abigail Marie Mabe