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Theses/Dissertations from 2022

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Importance of the Microhabitat and Microclimate Conditions in the Northern Gray-cheeked Salamander (Plethodon montanus) Across an Elevation Gradient, Trevor Chapman

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A Functional Study of Topological DNA Problem in Human T cells During Chronic Viral Infection, Xindi Dang

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Knockdown of C. elegans NAD Kinases NADK-1 or NADK-2 Induces an Antioxidant Response Without Affecting Lifespan, Henry Gong

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Investigating the PI3K/AKT/ATM Pathway, Telomeric DNA Damage, T Cell Death, and CRISPR/Cas9-mediated Gene Editing During Acute and Chronic HIV Infection, Sushant Khanal

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Validation of the 40 Hz Auditory Steady State Response as a Pharmacodynamic Biomarker of Evoked Neural Synchrony, Muhammad Ummear Raza

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The Mechanisms of Mitochondrial Dysfunction in T Cell Aging during Chronic Viral Infection, Madison B. Schank

Theses/Dissertations from 2021

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GABAergic-Related Pathology in the Anterior Cingulate Cortex of Postmortem Human Brain Tissue in Autism Spectrum Disorder, Gethien Andrew

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Endothelial Heat Shock Protein A12B and Yes-associated Protein Cooperatively Promote Angiogenesis Following Myocardial Infarction, Min Fan

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Trained Immunity Enhances the Immune Response and Maintains Microbiome Diversity in Aging and Sepsis, P. Spencer Gill

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Genital Chlamydia Infection is Influenced by the Female Sex Hormones Estrogen and Progesterone in Vivo, Amy Gail Gravitte

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Role of Ataxia Telangiectasia Mutated Kinase in Western-type Diet-induced Cardiac Outcomes under Basal and Ischemic Conditions, Mary Wingard

Theses/Dissertations from 2020

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Development, Expansion and Role of Myeloid-Derived Suppressor Cells in Post-Sepsis Immune Suppression, Tuqa Alkhateeb

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Axonal Regrowth of Olfactory Sensory Neurons After Chemical Ablation and Removal of Axonal Debris by Microglia, Rudy Chapman

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Prevention of Chronic Inflammation by Targeting Macrophage Integrin aDb2, Cady Forgey

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Behavioral and Neurobiological Evidence of Epigenetic Transmission in the Neonatal Quinpirole Rodent Model of Schizophrenia, Wesley Gill

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Understanding the Implications of Anandamide, an Endocannabinoid in an Early Land Plant, Physcomitrella patens, Md Imdadul Haq

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Immune Activation Induces Telomeric DNA Damage, Reduces Memory Precursors, and Promotes Short-lived Effector T Cell Differentiation in Chronic HCV Infection, Lam Nguyen

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A Novel Mode of Action of C-reactive Protein in Protecting Against Streptococcus pneumoniae Infection and Synergy with Antibiotics, Donald Ngwa

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Chronic Effects of Methylphenidate on Neuronal Viability and Plasticity, Hannah Oakes

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Protection Against Atherosclerosis by A Non-native Pentameric CRP that Shares its Ligand Recognition Functions with an Evolutionarily Distant CRP, Asmita Pathak

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Roles of Endothelial Cell Heat Shock Protein A12B and β-glucan, a reagent for trained Immunity in the Regulation of Inflammation in Sepsis, Fei Tu

Theses/Dissertations from 2019

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Exploration of Ataxia Telangiectasia and Rad3-Related’s (ATR’s) Role in Cell Death Regulation: Implications in Development, Cancer, and Stroke, Brian Cartwright

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The Distinct Expressions of Integrins αDβ2 and αMβ2 Differently Regulate Macrophage Migration in 3D Matrix in vitro and in Tissue during Inflammation, Kui Cui

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Role of ATM in T Cell Dysfunction During Chronic Viral Infections, Juan Zhao

Theses/Dissertations from 2018

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The Combined Neuropharmacology and Toxicology of Major 'Bath Salts' Constituents MDPV, Mephedrone, and Methylone, Serena Allen

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The Effect of Alcohol Consumption on Adipokine Secretion, Ashley DeGroat

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Quantitative Studies of Amyloidogenic Protein Residue Interaction Networks and Abnormal Ammonia Metabolism in Neurotoxicity and Disease, Jeddidiah Griffin

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Metabolic Plasticity in the Cellular Stress Response, Ying Li

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HIV Integrase Inhibitor Pharmacogenetics and Clinical Outcomes: An Exploratory Association Study, Derek E. Murrell

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Effects of Gender, Age, and Nutrition on Circadian Locomotor Activity Rhythms in the Flesh Fly Sarcophaga crassipalpis, Fritz Prohaska

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Characterization of Acyltransferases and WRINKLED Orthologs Involved in TAG Biosynthesis in Avocado, Md Mahbubur Rahman

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Virulence Regulation in Pseudomonas aeruginosa via the Alginate Regulators, AlgU and AlgR, the posttranscriptional regulator, RsmA, and the Two-component System, AlgZ/R, Sean Stacey

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SIP-428, a SIR2 Deacetylase Enzyme and Its Role in Biotic Stress Signaling Pathway, Bal Krishna Chand Thakuri

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Role of Ataxia-Telangiectasia Mutated Kinase in Cardiac Autophagy and Glucose Metabolism Under Ischemic Conditions, Patsy Thrasher

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Investigating the Interaction of Monoamines and Diel Rhythmicity on Anti-Predator Behavior in an Orb-Weaving Spider, Larinioides cornutus (Araneae: Araneae), Rebecca Wilson

Theses/Dissertations from 2017

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Role of Cannabinoid Receptor Type 2 (CB2) in Late Stage Atherosclerosis, Makenzie Fulmer

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A-type Lamins in Cell Cycle Regulation, Jaime L. Parman-Ryans

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Exogenous Ubiquitin: Role in Myocardial Inflammation and Remodeling Post- Ischemia/Reperfusion Injury, Stephanie Scofield

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Role of TLRs, Hippo-YAP1 Signaling, and microRNAs in Cardiac Repair and Regeneration of Damaged myocardium During Ischemic Injury, Xiaohui Wang

Theses/Dissertations from 2016

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An Investigation into Formulation and Therapeutic Effectiveness of Nanoparticle Drug Delivery for Select Pharmaceutical Agents, Dustin Cooper

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Strategies of Balancing: Regulation of Posture as a Complex Phenomenon, Allison Leich Hilbun

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Investigation of Novel Functions for DNA Damage Response and Repair Proteins in Escherichia coli and Humans, Benjamin A. Hilton

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Exploring the Relationship Between Behaviour and Neurochemistry in the Polyphenic Spider, Anelosimus studiosus (Araneae: Theridiidae), Jennifer B. Price

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In Vitro and In Vivo Characterization of Chlamydia and HSV Co-infection, Jessica A. Slade

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A novel role of human DNA damage checkpoint protein ATR in suppressing Ca2+ overload-induced PARP1-mediated necrosis, Hui Wang-Heaton

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Pharmacokinetics, Tissue Distribution, Synergistic Activity, and Antitumor Activity of Two Isomeric Flavones, Crystal L. Whitted

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Regulation of Acute and Chronic Immune Responses by β-Arrestin2, Hui Yan

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Endothelial HSPA12B is a Novel Protein for the Preservation of Cardiovascular Function in Polymicrobial Sepsis via Exosome MiR-126, Xia Zhang

Theses/Dissertations from 2015

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Role of Ataxia Telangiectasia Mutated Kinase in the Healing Process of the Heart Following Myocardial Infarction, Laura L. Daniel

Theses/Dissertations from 2014

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Cellular-based Brain Pathology in the Anterior Cingulate Cortex of Males with Autism Spectrum Disorder, Jessica D. Crawford

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Extracellular Ubiquitin: Role in Cardiac Myocyte Apoptosis and Myocardial Remodeling, Christopher Ray Daniels

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Novel Therapeutic Approaches for Ischemic Heart and Brain Injury: Modulation of Toll-Like Receptor-Mediated Signaling Pathways and PI3K/Akt Signaling, Chen Lu

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Regulation of C-reactive Protein Gene Expression and Function, Avinash N. Thirumalai

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A Comprehensive Study of the Effects of Neurotoxins on Noradrenergic Phenotypes, Neuronal Responses and Potential Intervention by Antidepressants in Noradrenergic Cells, Yan Wang

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HIF-1α in the Heart: Provision of Ischemic Cardioprotection and Remodeling of Nucleotide Metabolism, Joe Wu

Theses/Dissertations from 2013

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An Examination of the Inhibitory Effects of Antibiotic Combinations on Ribosome Biosynthesis in Staphylococcus aureus, Justin Beach

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Genetic Imbalances in Endometriosis Detected by Oligonucleotide-Array Based Comparative Genomic Hybridization, Natalie Burke

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Arrested and Aberrant: Effects of Amoxicillin in a Murine Model of Chlamydial Infection, Regenia Beth Phillips Campbell

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Identification and Characterization of Genetic Factors Involved in Candida-Bacterial Interactions, Sean J. Fox

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Mechanisms of the Anti-Pneumococcal Function of C-Reactive Protein, Toh B. Gang

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Microsporidia Spore Adherence and Host Cell Infection In Vitro, Cory A. Leonard

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New Insights into the Roles of Human DNA Damage Checkpoint Protein ATR in the Regulation of Nucleotide Excision Repair and DNA Damage-Induced Cell Death, Zhengke Li

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Novel Ester Substrates for the Detection and Treatment of Prostate Cancer, Christopher Allen McGoldrick

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Novel Roles of Replication Protein A Phosphorylation in Cellular Response to DNA Damage, Moises A. Serrano

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Bioengineering the Expression of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, and C-Reactive Protein in Yeast, Eliot T. Smith

Theses/Dissertations from 2012

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Prelamin A Influences a Program of Gene Expression In Regulation of Cell Cycle Control, Christina N. Bridges

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Detection and Purification of a Novel Natural Inhibitory Compound from an Isolated Strain of Rhodococcus Using an Agar Extraction Method, Megan Carr

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An Investigation of Bacterial Ribonucleases as an Antibiotic Target, Ashley Denise Frazier

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Stabilization of the Cardiac Nervous System During Cardiac Stress Induces Cardioprotection, David D. Gibbons

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The Effects of Nicotine Administration on Behavior and Markers of Brain Plasticity in a Rodent Model of Psychosis, Marla K. Perna

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Effects of Burn Injury on Biological Ethanol and Ethyl Glucuronide Concentrations, Trista Haupt Wright

Theses/Dissertations from 2011

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Role of Type 2 Cannabinoid Receptor (CB2) in Atherosclerosis., Courtney Denise Netherland

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Biopharmaceutic and Pharmacokinetic Studies of Sucrose Acetate Isobutyrate as an Excipient for Oral Drug Delivery., Martin Ray Tant

Theses/Dissertations from 2010

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The Effect of Sternocleidomastoid Muscle Activation Pattern and Feedback Condition on the Vestibular Evoked Myogenic Potential., Mary Jo Davenport

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Mosaic Analysis with Double Markers (MADM) as a Method to Map Cell Fates in Adult Mouse Taste Buds., Preston D. Moore

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The Multifaceted Contribution of Natural Killer Cells During Herpes Simplex Type-1 Viral Infection., Stacie N. Woolard

Theses/Dissertations from 2009

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Determining Putative Secondary Product Glucosyltransferase Expression During Citrus paradisi Growth and Development., Jala Daniel

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Dopamine D2 Receptor Priming Enhances Dopaminergic Response to Amphetamine in the Nucleus Accumbens: Role of the D1 and D2 Receptors., Kimberly Norris Huggins

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Localization of Calbindin-D28k in Extra-Embryonic Membranes of Two Oviparous Scincid Lizards., Shuo Li

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Nectin-1 is Degraded in Chlamydia trachomatis-Infected Genital Epithelial Cells and is Required for Herpes Simplex Virus Co-Infection-Induced C. trachomatis Persistence., Jingru Sun

Theses/Dissertations from 2008

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Elucidating the Role of the α7 Nicotinic Receptor in the Etiology of Schizophrenia., Michelle Johnson Chandley

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Identification of Chlamydial Iron-Responsive Proteins during Intracellular Growth., Brian D. Dill

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Antigen Trafficking within Chlamydia trachomatis-Infected Polarized Human Endometrial Epithelial Cells., David Kelley Giles

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Urinary Excretion of (1-3)-Beta-D-Glucans., Debra K. Head

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Expression, Purification, and Characterization of the Mast Cell Proteases Chymase and Cathepsin G., Brent E. Lockhart

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Characterization of Murine Cardiac Cholinergic Innervation and Its Remodeling in Type 1 Diabetes., Abigail Marie Mabe

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Structural and Biochemical Investigation of the Molecular Mechanisms of DNA Response and Repair in Humans and Escherichia coli., Steven Michael Shell

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Characterization of Heat Shock Protein A12B as a Novel Angiogenesis Regulator., Rebecca J. Steagall

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Herpes Simplex Virus Glycoprotein D/Host Cell Surface Interaction Stimulates Chlamydia trachomatis Persistence via a Novel Pathway., Jennifer Vanover

Theses/Dissertations from 2007

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Characterization of a 30S Ribsomal Subunit Intermediate Found in Escherichia coli Cells Growing with Neomycin and Paromomycin., Cerrone Renee Foster

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Localization of a Microsporidia ADAM (A Disintegrin and Metalloprotease Domain) Protein and Identification of Potential Binding Partners., Carrie E. Jolly

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T-cell Dysfunction by HCV Core Protein Involves PD-1/PD-L1 Signaling., Billy Ellis King

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1, Structural and Functional Studies of Human Replication Protein A; 2 DNA Damage Responses and DNA Repair Defects in Laminopathy-Based Premature Aging., Yiyong Liu

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Antibiotics that Inhibit 30S or 50S Ribosomal Subunit Formation: Hygromycin B, Quinupristin-Dalfopristin and XRP 2868., Susan Mabe McGaha

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Molecular Mechanisms of Interleukin-1beta-Stimulated Regulation of Angiogenesis in Cardiac Microvascular Endothelial Cells., Deidra Jill Hopkins Mountain

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Studies on a 50S Ribosomal Precursor Particle as a Substrate for erm E Methyltransferase Enzyme in Staphylococcus aureus ., Indira Pokkunuri

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Examination of Microsporidia Spore Adherence and Host Cell Infection In Vitro., Timothy Robert Southern

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Periplasmic Modification of the 1-Phosphate Group of Lipid A in Gram-Negative Bacteria., An Xuong Tran

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Mechanism of Transcriptional Regulation of C-Reactive Protein Gene Expression., Bhavya Voleti

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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury., Xingshun Xu