Honors Program

University Honors

Date of Award


Thesis Professor(s)

Matthew Palmatier

Thesis Professor Department

<--College of Arts and Sciences-->

Thesis Reader(s)

Gerald Deehan


Although cannabis is widely consumed by humans for the intoxicating effects that are mediated by delta-9 tetrahydrocannabinol (THC), pre-clinical models of THC self-administration have been difficult to establish. We hypothesized that THC may have reinforcement enhancing effects comparable to other drugs (e.g., nicotine and caffeine), which are also widely consumed by humans but difficult to establish as primary reinforcers in non-human animals. To investigate whether THC is a reinforcement enhancer, male (M, n=8) and female (F, n=8) rats were shaped to self-administer a reinforcing saccharin (SACC) solution (0.2% w/v) in standard operant chambers equipped with infrared beams to monitor locomotor activity. At baseline, we found a significant sex difference for active lever responses and reinforcers earned (F


East Tennessee State University

Document Type

Honors Thesis - Withheld

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