Date of Award
Thesis Professor Department
Mathematics and Statistics
Previous research suggests that the efficacy of Ertapenem, a carbapenem antibiotic administered intravenously, is related to a patient’s body mass index. Using an existing physiologically based pharmacokinetic (PBPK) model for Ertapenem, we constructed a least squares inverse problem to determine an optimal dose for males with varying body weights and heights. The criteria for an optimal dose was based upon pharmacokinetic and pharmacodynamic (PK/PD) parameters calculated for a male with a body height of 175 cm and a weight of 72 kg. We also adjusted dosing intervals to ensure that effective concentration of drug between doses was the same for all males regardless of BMI.
East Tennessee State University
Honors Thesis - Withheld
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Jewett, Bethany, "Investigation of optimal dosing strategies for Ertapenem for varying BMI using mathematical modeling" (2019). Undergraduate Honors Theses. Paper 500. https://dc.etsu.edu/honors/500
Copyright by the authors.
Available for download on Wednesday, May 06, 2020