Honors Program

Midway Honors

Date of Award

5-2014

Thesis Professor(s)

Robert Wondergem

Thesis Professor Department

Physiology

Thesis Reader(s)

Darrell Moore, Tom Ecay

Abstract

Electrical potentials exist across the membranes of nearly every cell type in the body. In addition, excitable cells, such as neurons, myocytes and even some endocrine cells elicit electrochemical fluctuations, action potentials (AP), in the cell membrane to initiate cell-to-cell communication or intracellular processes. The basis for the electrical potential is rooted within an array of complex interactions between monovalent ions and their associated membrane channels and transporters that regulate the flux of these charged species across the hydrophobic bilayer. Here, an expansion of our recently published work [1] will serve to explore the modern concepts regarding the origin of the AP as well as to examine the mechanisms by which intracellular calcium ([Ca2+]i) is regulated within the HL-1 mouse cardiac myocyte.

Document Type

Honors Thesis - Open Access

Copyright

Copyright by the authors.

Share

COinS