Miglustat Effects on the Basal Nasal Potential Differences in Cystic Fibrosis
Document Type
Article
Publication Date
1-1-2013
Description
A recent study by Leonard, Lebecque, Dingemanse, and Leal [1] tested the effect of Miglustat, an alpha inhibitor on the cystic fibrosis conductance regulator gene using total chloride secretion in the nasal epithelium as the key variable estimated from basal nasal potential differences. The conclusion was drawn that “There was no evidence of a treatment effect on any nasal potential difference variable.” This conclusion may not be correct because of a slight misinterpretation of their statistical results. There also is a question of whether longer exposure periods than 8 days would have produced a more pronounced effect.
Citation Information
Jenkins, Bradlee A.; and Glenn, L. Lee. 2013. Miglustat Effects on the Basal Nasal Potential Differences in Cystic Fibrosis. Journal of Cystic Fibrosis. Vol.12(1). 88. https://doi.org/10.1016/j.jcf.2012.06.003 ISSN: 1569-1993