Stability of Compounded Trilostane Suspension in Cod Liver Oil
Trilostane is a synthetic steroid analog used to treat canine hyperadrenocorticism. For small dogs, the dose found in commercially available dosage forms of trilostane is sometimes too high. Compounding trilostane in a liquid diluent provides an option for more precise dosing and adjustments, and can be easier to administer, versus a tablet or capsule. Trilostane suspends well in cod liver oil, which is generally palatable to dogs. The stability of a compounded trilostane suspension in cod liver oil stored at room temperature was investigated for 90 days. Compounded trilostane retained stability, defined as maintaining 90–105% labeled value, for 60 days when stored in amber glass bottles. However, drug potency fell >10% below the labeled value when stored in amber plastic bottles after 7 days.
Crosby, Jesse; and Brown, Stacy D.. 2017. Stability of Compounded Trilostane Suspension in Cod Liver Oil. The Veterinary Journal. Vol.228 15-17. https://doi.org/10.1016/j.tvjl.2017.10.001 ISSN: 1090-0233