Title

Isoflurophate

Document Type

Book Contribution

Publication Date

1-1-2007

Description

Isoflurophate is a long acting cholinesterase inhibitor and potent miotic. It works as an indirect acting parasympathomimetic agent to reduce intraocular pressure. Also known as diisopropyl phosphofluoridate (Dyflos), it is an irreversible organophosphate cholinesterase inhibitor. It and its analogues were studied extensively during the Second World War as substances that could be employed as war gases because of their volatility and rapid absorption from the lungs. Due to its toxicity it is only used in the treatment of patients with open angle glaucoma or other chronic glaucomas which are not controlled with other less toxic short acting agents.

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