Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors
Four known small molecule uracil-DNA glycosylase (UNG) inhibitors were synthesized and tested against human melanoma cells, IgR3 and MM200. They were found to be effective against cell proliferation at micromolar concentrations and to operate through a nonapoptotic mechanism. Thus, small molecules that target UNG may be useful as potential chemotherapeutic agents against human melanoma.
Xiao, Mei; Zhu, Bi Ke; and Yu, Lin Jiang. 2008. Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors. Letters in Drug Design and Discovery. Vol.5(2). 108-110. https://doi.org/10.2174/157018008783928445 ISSN: 1570-1808