Title

A Graph-Theoretic Model Based on Primary and Predicted Secondary Structure Reveals Functional Specificity in a Set of Plant Secondary Product UDP-Glucosyltransferases

Document Type

Conference Proceeding

Publication Date

12-1-2009

Description

Plant secondary product glucosyltransferases (GTs), specifically flavonoid GTs, are being used as the model proteins. These GTs catalyze transfer of glucose from UDP-glucose to a wide variety of secondary metabolites. Although primary structure information is available for many putative GTs through genomic and proteomic databases, a direct biochemical link between structure and function exists for only subset of the proteins. In this work we utilize the primary sequences and predicted secondary structures of a set of GTs to build several graph-theoretic models of each GT. We determine graphical invariants and utilize them as descriptors of the biomolecules. Statistical analysis of the descriptors reveals additional information regarding substrate specificity.

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