Prevalence and Correlates of Major Depressive Disorder Among Opiod Dependent Patients: Finding from a Randomized Clinical Trial

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Background: The United States is currently experiencing an epidemic of opioid abuse. Individuals with opioid dependence may also have major depressive disorder (MDD) as a co-morbid state. MDD is one of the commonest mental health problems in the United States, affecting approximately 7% of the adult population. The relationship between opioid dependence and MDD and the factors that correlate with them have not been fully investigated. This study is designed to evaluate the prevalence of MDD and its associations with risk factors and health conditions such as age, race, sex, liver problems, anxiety, bipolar disorders, hypertension, heart diseases, neurologic damage, head injury and alcohol in opioid dependent patients. Method: The study population comprises of 1646 opioid dependent patients from the National Drug Abuse Treatment Trial Network (CTN) - CTN 0027. Baseline information on sex, age, race, liver disease, bipolar disorder, anxiety, neurologic damage, heart disease, hypertension, alcohol dependence, allergies, gastrointestinal problems and head injury were collected. Data analysis was done using univariate and multiple logistic regression to estimate the odds ratio (OR) and 95% confidence interval (CI). Results: The prevalence of MDD among patients with opioid dependence was 28.3% (22.8% for males and 39.5% for females). The prevalence initially increased with increasing age stratum but declined after age 50 years with the highest prevalence in the age 36 – 49years group. The multiple logistic regression analysis showed that MDD in opioid dependent patients was significantly associated with being female (OR =1.83, 95%CI = 1.32 -2.55; p = 0.003), liver disease (OR = 1.64, 95%CI = 1.15 - 2.34, p = 0.006), anxiety (OR = 6.12, 95%CI = 4.44 - 8.44, p


Atlanta, GA

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