Hematopoietic Stem Progenitor Cells Prevent Chronic Stress-Induced Lymphocyte Apoptosis
Physical or psychological chronic stress can suppress the immune system. However, the mechanisms remain to be elucidated. We investigated the effect of hematopoietic stem-progenitor cells (HSPCs) on chronic stress-induced the alterations of immune responses. We demonstrate that HSPCs prevents stress-induced lymphocyte apoptosis. Moreover, we also demonstrate that the protective effect of HSPCs on stress-induced lymphocyte reduction exerts by steroid hormones. Furthermore, we reveal that chronic stress-induced T cell-mediated immune responses contributes to the protective effect of HSPCs. These results indicate that HPSCs might offer a novel therapeutic strategy against the deleterious effects of chronic stress on the immune system.
Zhou, Yu; Li, Hui; Siddiqui, Nausheen; Caudle, Yi; Zhang, Haiju; Elgazzar, Mohamed; and Yin, Deling. 2017. Hematopoietic Stem Progenitor Cells Prevent Chronic Stress-Induced Lymphocyte Apoptosis. Journal of Neuroimmunology. Vol.309 72-76. https://doi.org/10.1016/j.jneuroim.2017.05.014 PMID: 28601292 ISSN: 0165-5728