Growth and Growth Hormone in Turner Syndrome: Looking Back, Looking Ahead
Short stature is the most ubiquitous feature of Turner syndrome (TS). Today, many girls with TS are treated with recombinant human growth hormone (GH) to accelerate growth in childhood and to improve adult height. Here, we will review the history of our understanding of growth in TS, reflect on the path of clinical trials ultimately leading to regulatory approval for clinical use of GH, discuss factors associated with growth outcomes and survey the current unanswered questions about growth and GH in TS.
Los, Evan; and Rosenfeld, Ron G.. 2019. Growth and Growth Hormone in Turner Syndrome: Looking Back, Looking Ahead. American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. Vol.181(1). 86-90. https://doi.org/10.1002/ajmg.c.31680 PMID: 30811776 ISSN: 1552-4868