Angioedema: A Life-threatening Complication of Tissue Plasminogen Activator
Document Type
Article
Publication Date
3-29-2018
Description
Angioedema is a localized, non-pitting, non-dependent, submucosal, and subcutaneous swelling resulting from the extravasation of fluid into the interstitium due to the increased production of plasma kinins and histamine. It can present with urticaria or anaphylaxis and is usually associated with angiotensin-converting enzyme inhibitors (ACEis), complement deficiencies, or the side effects of tissue plasminogen activator (tPA). Orolingual angioedema following tPA for acute ischemic stroke is a transient, self-resolving hemifacial swelling contralateral to neurological deficits that can rarely progress to the airway, compromising it and leading to a life-threatening situation if not managed promptly.
Citation Information
Khalid, Muhammad; Kanaa, Majd; Alkawaleet, Yazan; and Ayub, Muhammad T., "Angioedema: A Life-threatening Complication of Tissue Plasminogen Activator" (2018). ETSU Faculty Works. 192.
https://dc.etsu.edu/etsu-works-2/192
