Degree Name
MS (Master of Science)
Program
Chemistry
Date of Award
5-2021
Committee Chair or Co-Chairs
Hua Mei
Committee Members
Greg Bishop, Catherine McCusker
Abstract
This study aims to prepare theranostic nanoparticles (NPs) that are expected to increase cancer diagnostics and therapeutic efficacy. We prepared the NPs constituting carbon dots (CDs) as an imaging agent, folic acid as a targeting agent, doxorubicin (DOX), or gemcitabine (GEM) as chemotherapy agents. The NPs include noncovalent FA-CDs-DOX, covalent CDs-FA-DOX, and covalent FA-CDs-GEM. Through ultraviolet-visible spectroscopy, fluorescence spectroscopy, and Fourier transform-infrared spectroscopy, the fabrication of these NPs was confirmed. It was discovered that the high drug loading efficiency is the noncovalent series while the high drug loading capacity is the covalent series The in-vitro pH-dependent drug release data indicate the NPs release more drugs at around pH 5.0 than at pH 7.4. The NPs sizes are between 2-5 nm. The Cell viability was investigated using the Alamar Blue assay and the three NPs complexes exhibited strong therapeutic efficacy against MDA-MB-468 breast cancer cells as compared with CDs-drug.
Document Type
Thesis - unrestricted
Recommended Citation
Babanyinah, Godwin Kweku, "Theranostic Nanoparticles Folic Acid-Carbon Dots-Drug(s) for Cancer" (2021). Electronic Theses and Dissertations. Paper 3892. https://dc.etsu.edu/etd/3892
Copyright
Copyright by the authors.
Included in
Analytical Chemistry Commons, Medicinal-Pharmaceutical Chemistry Commons, Organic Chemistry Commons