MS (Master of Science)
Date of Award
Committee Chair or Co-Chairs
Aleksey Vasiliev, Abbas G. Shilabin
Hydroxytyrosol, 3,4-dihydroxyphenolethanol, a naturally occurring polyphenol most common in olive tree (Olea europaea), is one of the most effective member of the polyphenols family, because of its remarkable antioxidant activity, its ability to inhibit oxidation of low density lipids (LDL), and its protection against DNA oxidative damage. Hydroxytyrosol, which is widely used in cosmetics and food supplements industries, can be purchased as an olive oil extract that contains low concentration of hydroxytyrosol besides other polyphenols. The price and low natural abundance of hydroxytyrosol make alternative synthetic sources very attractive. In this research, a novel method for the synthesis of pure hydroxytyrosol from a commercially inexpensive precursor catechol was developed; this can satisfy the increasing market demand and provide a more economical alternative source for this valuable polyphenol.
Thesis - unrestricted
Onobun, Emmanuel, "A Novel Method for Synthesis of Hydroxytyrosol" (2017). Electronic Theses and Dissertations. Paper 3267. https://dc.etsu.edu/etd/3267
Copyright by the authors.