Degree Name
MS (Master of Science)
Program
Chemistry
Date of Award
8-2017
Committee Chair or Co-Chairs
Ismail Kady
Committee Members
Aleksey Vasiliev, Abbas G. Shilabin
Abstract
Hydroxytyrosol, 3,4-dihydroxyphenolethanol, a naturally occurring polyphenol most common in olive tree (Olea europaea), is one of the most effective member of the polyphenols family, because of its remarkable antioxidant activity, its ability to inhibit oxidation of low density lipids (LDL), and its protection against DNA oxidative damage. Hydroxytyrosol, which is widely used in cosmetics and food supplements industries, can be purchased as an olive oil extract that contains low concentration of hydroxytyrosol besides other polyphenols. The price and low natural abundance of hydroxytyrosol make alternative synthetic sources very attractive. In this research, a novel method for the synthesis of pure hydroxytyrosol from a commercially inexpensive precursor catechol was developed; this can satisfy the increasing market demand and provide a more economical alternative source for this valuable polyphenol.
Document Type
Thesis - unrestricted
Recommended Citation
Onobun, Emmanuel, "A Novel Method for Synthesis of Hydroxytyrosol" (2017). Electronic Theses and Dissertations. Paper 3267. https://dc.etsu.edu/etd/3267
Copyright
Copyright by the authors.
Included in
Biochemistry Commons, Cardiovascular Diseases Commons, Medicinal-Pharmaceutical Chemistry Commons, Organic Chemistry Commons