MS (Master of Science)
Date of Award
Committee Chair or Co-Chairs
W. Andrew Clark, Jonathan Peterson, Edward Onyango
Infertility is one of the major problems of obesity. Studies have shown that administration of leptin reversed obesity-induced infertility in rats and mice. Coenzyme Q10 (CoQ10) is an antioxidant and also supplies the energy needed for ovulation and embryo development. We hypothesized that leptin when combined with CoQ10 could greatly improve obesity-induced infertility. The results showed a significant decrease in food intake, body weight, and the regular estrous cycle was restored after treatment with leptin+CoQ10. There was a significant increase (p10 significantly (p10 can improve fertility in obese infertile female rats. This study could provide a novel therapeutic strategy for the treatment of infertility and formulation of new drugs for the treatment of obesity-induced infertility in females.
Thesis - Open Access
Adedeji, Adekunle, "The Combined Effects of Leptin and Coenzyme Q10 in Ameliorating Obesity- Induced Infertility in Female Rats" (2016). Electronic Theses and Dissertations. Paper 3131. https://dc.etsu.edu/etd/3131
Copyright by the authors.