The Combined Effects of Leptin and Coenzyme Q10 in Ameliorating Obesity- Induced Infertility in Female Rats

Author

Adekunle Adedeji, East Tennessee State UniversityFollow

Degree Name

MS (Master of Science)

Program

Biology

Date of Award

8-2016

Committee Chair or Co-Chairs

Effiong Otukonyong

Committee Members

W. Andrew Clark, Jonathan Peterson, Edward Onyango

Abstract

Infertility is one of the major problems of obesity. Studies have shown that administration of leptin reversed obesity-induced infertility in rats and mice. Coenzyme Q₁₀ (CoQ₁₀) is an antioxidant and also supplies the energy needed for ovulation and embryo development. We hypothesized that leptin when combined with CoQ₁₀ could greatly improve obesity-induced infertility. The results showed a significant decrease in food intake, body weight, and the regular estrous cycle was restored after treatment with leptin+CoQ₁₀. There was a significant increase (p10 significantly (p10 can improve fertility in obese infertile female rats. This study could provide a novel therapeutic strategy for the treatment of infertility and formulation of new drugs for the treatment of obesity-induced infertility in females.

Document Type

Thesis - unrestricted

Recommended Citation

Adedeji, Adekunle, "The Combined Effects of Leptin and Coenzyme Q10 in Ameliorating Obesity- Induced Infertility in Female Rats" (2016). Electronic Theses and Dissertations. Paper 3131. https://dc.etsu.edu/etd/3131

Copyright

Copyright by the authors.