Degree Name
MS (Master of Science)
Program
Chemistry
Date of Award
12-2008
Committee Chair or Co-Chairs
Yu-Lin Jiang
Committee Members
David G. J. Young, Ismail O. Kady
Abstract
Two natural marine compounds, 3-bromo-4,5-dihydroxybenzaldehyde 2 and 2,3-dibromo-4,5-dihydroxybenzaldehyde 5 together with two novel derivatives, 3-bromo-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxybenzaldehyde 3 and 1-bromo-2,3-dimethoxy-5-nitrooxy-methylbenzene 9, were synthesized. Compounds 2, 3, and 5 were evaluated for their biological activity towards the inhibition of prostate cancer cell growth using staurosporine a a positive control. All three compounds have shown significant inhibition of prostate cancer cell growth. Compound 9 is yet to be evaluated.
Document Type
Thesis - unrestricted
Recommended Citation
Bannerman-Akwei, Laude, "Synthesis of Marine Chemicals and Derivatives as Potential Anti-Cancer Drugs." (2008). Electronic Theses and Dissertations. Paper 1990. https://dc.etsu.edu/etd/1990
Copyright
Copyright by the authors.