Degree Name
MS (Master of Science)
Program
Mathematical Sciences
Date of Award
8-2010
Committee Chair or Co-Chairs
Anant P. Godbole
Committee Members
Kesheng Wang, Robert B. Gardner
Abstract
Assortative Mating, the tendency for mate selection to occur on the basis of similar traits, plays an essential role in understanding the genetic variation on academic achievements and intelligence (IQ). It is an important mechanism explaining spousal concordance. We used principal component analysis (PCA) for spousal correlation. There is a significant positive correlation between spouses by the new variable PC1 (correlation coefficient=0.515, p<0.0001). We further research the genetic factor that affects IQ by using the same data. We performed a low density genome-wide association (GWA) analysis with a family-based association test to identify genetic variants that associated with intelligence as measured by WAIS full-score IQ (FSIQ). NTM at 11q25 (rs411280, p=0.000764) and NR3C2 at 4q31.23 (rs3846329, p=0.000675) were 2 novel genes that haven't been associated with IQ from other studies. This study may serve as a resource for replication in other populations and a foundation for future investigations.
Document Type
Thesis - unrestricted
Recommended Citation
Pan, Yue, "Spousal Concordance in Academic Achievements and Intelligence and Family-Based Association Studies Identified Novel Loci Associated with Intelligence." (2010). Electronic Theses and Dissertations. Paper 1734. https://dc.etsu.edu/etd/1734
Copyright
Copyright by the authors.