Resistance Training Increases the Expression of AMPK, mTOR, and GLUT4 in Previously Sedentary Subjects and Subjects with the Metabolic Syndrome.

Author

Andrew Steven Layne, East Tennessee State University

Degree Name

MA (Master of Arts)

Program

Kinesiology and Sport Studies

Date of Award

5-2010

Committee Chair or Co-Chairs

Charles A. Stuart

Committee Members

Michael H. Stone, Michael W. Ramsey, N. Travis Triplett

Abstract

Exercise has been considered a cornerstone of diabetes prevention and treatment for decades, but the benefits of resistance training are less clear. Nineteen non-diabetic subjects (10 metabolic syndrome, 9 sedentary controls) underwent 8 weeks of supervised resistance training. After training, strength and V̇ O_2max increased by 10% in both groups. Percent body fat decreased in subjects with the metabolic syndrome. Additionally, lean body mass increased in both groups (p<0.05). Expression of glucose transporter protein-4 (GLUT4), the principle insulin-responsive glucose transporter, increased significantly in both groups. 5-adenosine monophosphateactivated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) expression increased in both groups, indicating increased protein synthesis and mitochondrial biogenesis. Markers of insulin resistance measured by a euglycemic hyperinsulinemic clamp did not improve in subjects with the metabolic syndrome but increased significantly in control subjects (13%). Resistance training upregulates intracellular signaling pathways that may be beneficial for ameliorating the metabolic syndrome.

Document Type

Thesis - unrestricted

Recommended Citation

Layne, Andrew Steven, "Resistance Training Increases the Expression of AMPK, mTOR, and GLUT4 in Previously Sedentary Subjects and Subjects with the Metabolic Syndrome." (2010). Electronic Theses and Dissertations. Paper 1673. https://dc.etsu.edu/etd/1673

Copyright

Copyright by the authors.