Degree Name
MS (Master of Science)
Program
Chemistry
Date of Award
12-2013
Committee Chair or Co-Chairs
Cassandra Eagle
Committee Members
Ismail Kady, Hua Mei
Abstract
The goal of this research project was to synthesize derivatives of transresveratrol. In order for resveratrol to be activated and used by the body it needs to bind to Human Serum Albumin (HSA), a protein in blood plasma. The derivatives were synthesized to improve the ability of resveratrol to enter cells as well as improve their ability to bind to HSA. The three derivatives that were synthesized have converted one of the hydroxyl groups on resveratrol to an ether with a methylene chain terminated by a carboxylic acid. By varying the lengths of the methylene chain we varied the water solubility of the resveratrol derivative. This brought the research closer to the goal of determining how this would affect the binding ability to HSA. Currently three derivatives have been synthesized and purified once by column chromatography.
Document Type
Thesis - unrestricted
Recommended Citation
Ressler, Daniel, "Synthesis of Resveratrol Ester Derivatives" (2013). Electronic Theses and Dissertations. Paper 1234. https://dc.etsu.edu/etd/1234
Copyright
Copyright by the authors.