Degree Name
MS (Master of Science)
Program
Biomedical Sciences
Date of Award
8-2005
Committee Chair or Co-Chairs
Race L. Kao
Committee Members
Krishna Singh, Brian P. Rowe
Abstract
Miniswine underwent procedures to evaluate treating chronic ischemia with the implantation of autologous satellite cells and laser transmyocardial revascularization (TMR). The objective was to combine two therapies to restore cardiac function. This experiment involved three surgical procedures: (1) placing a constrictor on the coronary artery; (2) producing channels and implanting cells; (3) obtaining samples. The swine were divided into groups: Group 1, Ischemia; Group 2, Ischemia + Laser TMR; Group 3, Ischemia + Laser TMR+ Cells; Group 4, Ischemia + Cells. Sonomicrometry and Millar pressure transducers were used to determine contractility, left ventricular pressure, and pressure-volume loops. There were no significant differences (p<0.05)among the hemodynamic data except for Group 4, which produced significantly lower output values. Morphological evaluation revealed a significantly reduced scar area in Group 3. Although there was a significant difference in scar area, the phenomena behind this improvement as compared to the unimproved hemodynamic function is not understood.
Document Type
Thesis - unrestricted
Recommended Citation
Ibrahim, Esha, "Angiogenesis and Myogenesis in a Chronic Ischemic Heart." (2005). Electronic Theses and Dissertations. Paper 1058. https://dc.etsu.edu/etd/1058
Copyright
Copyright by the authors.