Stress- Induced Reinstatement of Nicotine addiction in a Rodent Model of Schizophrenia Heritability
Faculty Mentor
Russell Brown
Mentor Home Department
Behavioral Neuroscience
Short Abstract
A rodent model of schizophrenia heritability was established by injecting the P generation with a dopamine agonist, quinpirole, as neonates and breeding these rats to produce an F1 generation. The F1 generation was shown to exhibit symptoms of dopamine sensitivity similar to the P generation. The F1 generation went through a stress induced reinstatement test with nicotine. Four groups of rats underwent testing: rats that were spawned from parents that had only been treated with saline as neonates and treated with saline through the experiment, rats spawned from saline parents and given nicotine, rats spawned from quinpirole parents and given saline, and lastly, rats spawned from quinpirole parents and given nicotine. A pretest was performed to determine initial preference in a conditioned place preference set up. A conditioning phase was performed. A post test was done after the conditioning. An extinction phase was performed. A post test was done after this, and then a stress induced reinstatement test was performed with a restraint stress. Early results have shown that the rats spawned from quinpirole parents and given nicotine had a greater stress induced reinstatement of conditioned place preference than other groups. (I am unable to summarize more results or specific results as this research is ongoing -Thank you for your understanding)
Category
Health
Start Date
5-4-2024 8:00 AM
End Date
5-4-2024 9:00 AM
Location
D.P. Culp Center Room 272 (East Tennessee Room)
Stress- Induced Reinstatement of Nicotine addiction in a Rodent Model of Schizophrenia Heritability
D.P. Culp Center Room 272 (East Tennessee Room)
A rodent model of schizophrenia heritability was established by injecting the P generation with a dopamine agonist, quinpirole, as neonates and breeding these rats to produce an F1 generation. The F1 generation was shown to exhibit symptoms of dopamine sensitivity similar to the P generation. The F1 generation went through a stress induced reinstatement test with nicotine. Four groups of rats underwent testing: rats that were spawned from parents that had only been treated with saline as neonates and treated with saline through the experiment, rats spawned from saline parents and given nicotine, rats spawned from quinpirole parents and given saline, and lastly, rats spawned from quinpirole parents and given nicotine. A pretest was performed to determine initial preference in a conditioned place preference set up. A conditioning phase was performed. A post test was done after the conditioning. An extinction phase was performed. A post test was done after this, and then a stress induced reinstatement test was performed with a restraint stress. Early results have shown that the rats spawned from quinpirole parents and given nicotine had a greater stress induced reinstatement of conditioned place preference than other groups. (I am unable to summarize more results or specific results as this research is ongoing -Thank you for your understanding)