Utilizing Transposon Mutagenesis to Identify Genetic Elements Important for Polymicrobial Interactions

Faculty Mentor

Dr. Sean Fox

Mentor Home Department

Health Sciences

Short Abstract

Microorganisms interact in symbiotic and antagonistic relationships. These unique interactions can be used to identify novel targets and understand microbial diseases. A genetic library of A. faecalis strains was constructed by transposon mutagenesis and screened to determine the loss-of-function of A. faecalis’ inhibition of Bacillus, Candida, and Staphylococcus. These results are important in determining the genetic mechanism in which A. faecalis inhibits growth and how this information can be used to thwart common human pathogens at a clinical level.

Category

Science and Technology

Start Date

24-4-2023 9:30 AM

End Date

24-4-2023 9:45 AM

Location

D.P. Culp Center Room 271J

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Apr 24th, 9:30 AM Apr 24th, 9:45 AM

Utilizing Transposon Mutagenesis to Identify Genetic Elements Important for Polymicrobial Interactions

D.P. Culp Center Room 271J

Microorganisms interact in symbiotic and antagonistic relationships. These unique interactions can be used to identify novel targets and understand microbial diseases. A genetic library of A. faecalis strains was constructed by transposon mutagenesis and screened to determine the loss-of-function of A. faecalis’ inhibition of Bacillus, Candida, and Staphylococcus. These results are important in determining the genetic mechanism in which A. faecalis inhibits growth and how this information can be used to thwart common human pathogens at a clinical level.