A Case Report of Treatment of Hyperkalemia Secondary to Rhabdomyolysis in the Emergent Perioperative Setting
Location
Culp Center Ballroom
Start Date
4-25-2023 9:00 AM
End Date
4-25-2023 11:00 AM
Poster Number
96
Faculty Sponsor’s Department
Surgery
Name of Project's Faculty Sponsor
Fernando Zepeda
Competition Type
Competitive
Type
Poster Case Study Presentation
Project's Category
Critical Care
Abstract or Artist's Statement
Introduction — Hyperkalemia, defined as serum potassium >6.0mmol/L, affects ±6% of people with kidney disease and is a contraindication to surgery due to the perioperative risk of potentially fatal cardiac dysrhythmia (1,2,3). When emergency surgery cannot be avoided, hyperkalemia must be managed perioperatively using a variety of traditional practice patterns which vary in efficacy (3,4,5). We present a case report of successful rapid correction of hyperkalemia in a 67-year- old man with a history of chronic kidney disease who presented to the emergency department for acute compartment syndrome in need of emergent fasciotomy to prevent loss of limb.
Methods — Since emergent treatment of hyperkalemia is often managed through a combination of medications with multiple mechanisms of action, we reviewed available related literature in PubMed in order to present this educational case report.
Patient Presentation — At the time of presentation, our patient’s serum potassium was 7.7mmol/L, creatinine kinase was 33,160U/L, and an ECG revealed a first-degree AV node block with slight ST depression. Following intubation, as a team of surgeons started extensive fasciotomy of his arm, our anesthesia team gave several medications in tandem—calcium gluconate to stabilize cardiac myocytes and prevent ventricular arrythmia, coadministration of dextrose and insulin to induce an intracellular shift of potassium, sodium bicarbonate to induce cellular hydrogen/potassium exchange, and albuterol to increase cellular uptake of potassium via β2 adrenergic receptors (1,6). The patient’s hyperkalemia improved from 7.7 to 3.7 (normal 3.5 – 5.1mmol/L) over 4 hours.
Discussion and Conclusion — Our review of available literature identified several methods of treatment of hyperkalemia, some with limitations to use which we believe support our team’s approach to treatment in this case report (6). Calcium salts are integral to the treatment of hyperkalemia by stabilizing cardiac myocytes, however they do not directly influence serum or total body potassium levels. Our report adds to a growing pool of existing case reports and small studies documenting safe, efficacious emergent treatment of hyperkalemia. It also describes the utility of the anesthesiologist in providing safe, effective perioperative medical care.
A Case Report of Treatment of Hyperkalemia Secondary to Rhabdomyolysis in the Emergent Perioperative Setting
Culp Center Ballroom
Introduction — Hyperkalemia, defined as serum potassium >6.0mmol/L, affects ±6% of people with kidney disease and is a contraindication to surgery due to the perioperative risk of potentially fatal cardiac dysrhythmia (1,2,3). When emergency surgery cannot be avoided, hyperkalemia must be managed perioperatively using a variety of traditional practice patterns which vary in efficacy (3,4,5). We present a case report of successful rapid correction of hyperkalemia in a 67-year- old man with a history of chronic kidney disease who presented to the emergency department for acute compartment syndrome in need of emergent fasciotomy to prevent loss of limb.
Methods — Since emergent treatment of hyperkalemia is often managed through a combination of medications with multiple mechanisms of action, we reviewed available related literature in PubMed in order to present this educational case report.
Patient Presentation — At the time of presentation, our patient’s serum potassium was 7.7mmol/L, creatinine kinase was 33,160U/L, and an ECG revealed a first-degree AV node block with slight ST depression. Following intubation, as a team of surgeons started extensive fasciotomy of his arm, our anesthesia team gave several medications in tandem—calcium gluconate to stabilize cardiac myocytes and prevent ventricular arrythmia, coadministration of dextrose and insulin to induce an intracellular shift of potassium, sodium bicarbonate to induce cellular hydrogen/potassium exchange, and albuterol to increase cellular uptake of potassium via β2 adrenergic receptors (1,6). The patient’s hyperkalemia improved from 7.7 to 3.7 (normal 3.5 – 5.1mmol/L) over 4 hours.
Discussion and Conclusion — Our review of available literature identified several methods of treatment of hyperkalemia, some with limitations to use which we believe support our team’s approach to treatment in this case report (6). Calcium salts are integral to the treatment of hyperkalemia by stabilizing cardiac myocytes, however they do not directly influence serum or total body potassium levels. Our report adds to a growing pool of existing case reports and small studies documenting safe, efficacious emergent treatment of hyperkalemia. It also describes the utility of the anesthesiologist in providing safe, effective perioperative medical care.